What Is Tranq Xylazine?
These severe wounds, called necrosis, increase the risk of amputation more than other injectable drugs, according to the DEA. Xylazine is a central nervous system depressant that can cause drowsiness and amnesia and slow a person’s breathing, heart rate and blood pressure to dangerously low levels. Experts still recommend administering Narcan if someone might be experiencing an overdose, especially since xylazine is so often combined with opioids. But people should know that it won’t address the impact of xylazine on breathing, and call emergency medical services either way. The percentage of xylazine-related overdose deaths increased from 2% to 26% from 2015–20 in Pennsylvania.
- Naloxone should be given in response to any suspected drug overdose to reverse any possible opioid effects.
- The company that produces them, BTNX, told STAT News that the strips would be sold for $200 per box of 100 test strips — a much higher price than similar test strips that can check for the presence of fentanyl in drugs.
- Eyo encourages calling for emergency care if an individual responds passively to naloxone.
- Just this week, Senate Majority Leader Chuck Schumer held a press conference in Watertown, N.Y., to outline his plan to prevent xylazine-related overdoses, as North Country Public Radio reports.
Xylazine is a non-opioid sedative commonly used for procedural sedation in veterinary medicine. Xylazine is in a class of medications called alpha-2 adrenergic agonists. This means it is not an opioid, but instead is more chemically similar to other sedative medications that decrease activity and have a calming, relaxing effect such as clonidine (an antihypertensive medication).
Unlike mainstream opioids like fentanyl or heroin, there’s no simple antidote for tranq exposure and overdose. When humans overdose on tranq, reports show that the effects can last anywhere from 8 to 72 hours (3 days). When you overdose on drugs that contain traces of tranq, it can cause dangerous side effects. However, these test strips are often only available to medical professionals. A medicine used to sedate animals is now being sold illegally as a thrill for humans.
Is there a treatment for xylazine overdose in humans?
Unlike abscesses, which are common with injected drugs, xylazine wounds will start out resembling blisters that then open and expand, leading to the risk of infection that Dittmore referenced and growing wider instead of deeper. Xylazine is a central nervous system depressant, Dittmore said, which has a sedative effect and depresses breathing. It is not an opiate, but those effects combined with an opiate can stop someone’s breathing, causing an overdose. Most of the existing research on xylazine was conducted in animal studies as human trials were shut down.
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But on the streets it’s known as “tranq” or “tranq dope”, and it’s been linked to horrific side effects and a growing number of deadly overdoses across the country. Although it is not intended for human use, xylazine is a common contaminant of illicit drugs in the U.S. Xylazine use causes sleepiness and a slow respiratory rate and might result in development of necrotic skin wounds (skin wounds with dead tissue). In November 2022, the FDA issued an alert warning healthcare professionals about xylazine being mixed with opioids like fentanyl and heroin and the risks to patients exposed to xylazine. In April 2023, the White House designated xylazine an “emerging drug threat”. This will allow the government to boost law enforcement, health care strategies, and data review to help fight the drug on the streets.
Food and Drug Administration (FDA) for use in humans because in clinical trials it caused severe central nervous system (CNS) depression or sedation in humans. Although opioid reversal drugs don’t work on xylazine, healthcare providers should still administer naloxone as the first response to a suspected overdose. Xylazine involvement should be suspected if multiple doses of naloxone don’t revive the patient, according to the FDA. An antagonist that reverses the sedative effects of xylazine, called atipamezole, is used in veterinary medicine.
Typically, rescuers use a medication called naloxone (often sold as Narcan) to reverse fentanyl overdoses, but if someone takes too much fentanyl mixed with xylazine, even Narcan might not wake them. Rescuers might end up using too much of the medication, which could make the person vomit and possibly choke. The substance was first found mixed with heroin in Puerto Rico as early as two decades ago. Today alcoholism: definition symptoms traits causes treatment the national center of the crisis is Philadelphia, where xylazine appeared in the drug supply as early as 2006, and was found in over 90% of the city’s lab-tested dope samples in 2021. Yes, repeated exposure to xylazine may lead to dependence, addiction and withdrawal symptoms, which may include agitation, vision changes, disabling migraines or severe anxiety when doses are decreased or stopped.
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Humans are about 10 to 20 times more sensitive to xylazine than animals are, Driessen said. It’s most commonly used in cattle as it’s one of the few sedatives studied in food animals, said Dr. Bernd Driessen, professor of anesthesiology at the University of Pennsylvania School of Veterinary Medicine. While it has been given in the past for household pets, the sedative is now typically used for larger animals like horse, sheep and elk.
Reversal agents regularly used in veterinary medicine should not be used in humans because it is not known if they are safe or effective in this population. Healthcare providers should provide appropriate supportive care to patients who do not respond adequately to naloxone administration, if given. Xylazine can cocaine kill you in a polysubstance exposure may include symptoms such as low blood pressure, fast heart rate and abnormal heart rhythms. Withdrawal can occur in people who abruptly discontinue the use of xylazine. Xylazine withdrawal can result in markedly elevated blood pressure, a rapid heart rate, and agitation.